Ten men have been charged with offences including rape, sexual assault and trafficking of at least five girls aged between 16 and 18.
West Midlands Police allege the offences were committed in Coventry between May and September 2012.
Five of the men are due to appear at the city’s crown court in November.
Five others will appear before magistrates in Coventry later. The accused are aged between 19 and 30, a police spokesman said.
Three brothers, Gulfraz Banaris, 20, and Ifaraz Banaris, 25, both of Deedmore Road, Wood End, and Izthkhab Banaris, 24, of Eld Road, all Coventry, are charged with conspiracy to traffic girls across the city.
Gulfraz and Izthkhab Banaris are also accused of rape.
They appeared before magistrates on Thursday and were remanded in custody to appear again on 7 November.
Two other brothers, Isa Iqbal, 21, and Ismail Iqbal, 20, both of no fixed address, also face trafficking charges and will appear in court in November.
Five other men are due to appear in court in Coventry later in connection with the same inquiry.
Ricardo Hinkson, 23, from Telfer Road, Radford; Amir Mahmood, 27, of Blackwell Road, both Coventry and Tasveer Hussain, 30, of Canal Road, Foleshill, have been charged with conspiracy to traffic within the UK for the purposes of sexual exploitation.
Saleem Hussain, 30, of Beake Avenue, Coventry, faces a charge of sexual assault, and 25-year-old Khezer Hussain, from Bordesley Green East, Stechford, Birmingham, has been charged with an offence of rape.
A spokesman said the five girls were being supported by specially-trained police officers and staff from Coventry City Council’s children’s services section.